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2-Methoxyestradiol说明

发布日期:2018-04-24 ??浏览次数:0
核心提示:2-Methoxyestradiol 是一种 microtubule 和 HIF-1 抑制剂,在秋水仙碱位点或附近结合到 tubulin,且抑制微管聚合,通过干扰正常微管功能而发挥作用。
2-Methoxyestradiol 是一种 microtubuleHIF-1 抑制剂,在秋水仙碱位点或附近结合到 tubulin,且抑制微管聚合,通过干扰正常微管功能而发挥作用。
Valspodar产品描述:Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator. In Vitro: Valspodar (PSC 833) has no cytotoxicity effects at up to the concentration of 0.75 μg/mL. Valspodar (0.25, 0.5 and 0.75 μg/mL) and DOX-L are added to the DOX resistant cells, and cell kill efficacy of MDR cell type increases significantly when valspodar is administered alongside DOX-L. Valspodar (0.5 and 0.75 μg/mL), in combination with all concentrations of DOX, are most toxic and kill more than 70% of the resistant cells[1]. Pretreatment with PSC833 decreases the IC50 value of mitoxantrone in MDA-MB-435mdr cells to 0.4±0.02 μM in MDR cells and almost completely reverses the resistance of MDR cells to mitoxantrone[3]. In Vivo: valspodar (10 mg/kg, o.p.) exhibits minimal blood-cell partitioning as reflected in its low mean blood-to-plasma ratio of approximately 0.52. Valspodar displays properties of s


公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。
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产品链接:www.medchemexpress.cn/Valspodar.html


Purity:98%
MWt:302.4079
Formula:C19H26O3
SMILES:OC1=CC2=C([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC2)[H])[H])O)C)[H])C=C1OC
Pathway:Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; metabolic Enzyme/Protease;
Mechanisms:Autophagy; HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin;
Research Area:Cancer
电话: 021-58955995
网址: www.MedChemExpress.cn
地址: 上海市浦东新区蔡伦路720号2号楼3层
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关键词: 2-Methoxyestradiol
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